Isaiah 13: 19 - 22: And Babylon, the glory of kingdoms, the beauty of the Chaldees' excellency, shall be as when God overthrew Sodom and Gomorrah. It shall never be inhabited, neither shall it be dwelt in from generation to generation: neither shall the Arabian pitch tent there; neither shall the shepherds make their fold there. But wild beasts of the desert shall lie there; and their houses shall be full of doleful creatures; and owls shall dwell there, and satyrs shall dance there. And the wild beasts of the islands shall cry in their desolate houses, and dragons in their pleasant palaces: and her time is near to come, and her days shall not be prolonged.
Owls are associated with destruction in the Bible; when God destroyed a city or a nation, then it became the dwelling place for these birds of the night.
The movies and popular novels (such as Harry Potter) featuring owls; the soft toys and posters portraying these creatures is a sign to the age that God is about to bring sudden destruction upon the earth, for the third woe (Armageddon) cometh quickly.