Revelation 15: 1: And I saw another sign in heaven, great and marvellous, seven angels having the seven last plagues; for in them is filled up the wrath of God.
A plague fell upon each church age after the people rejected the message for their age. Each plague fell near or after the conclusion of the church age.
The Antonine Plague (it began in approximately A.D. 165) fell upon Ephesus (A.D. 53 to A.D. 170).
The Cyprian Plague (it began in approximately A.D. 251) fell upon Smyrna (A.D. 170 to A.D. 312).
The Justinian Plague (it began in approximately A.D. 541) fell upon Pergamos (A.D. 312 to A.D. 606).
The Black Plague (it began in approximately A.D. 1347) fell upon Thyatira (A.D. 606 to A.D. 1520).
Cholera (it began in approximately A.D. 1816) fell upon Sardis (A.D. 1520 to A.D. 1750).
Spanish Influenza (the 1918 Flu Pandemic) fell upon Philadelphia (A.D. 1750 to 1906).
Aids and Cancer is falling upon Laodicea (1906 to ????).